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Placebo capsules were given to control subjects at the same times. In the study, the placebo group had higher IgE antibodies to the birch allergen than those who took Pycnogenol during the allergy season [17]. The 2012 study on the anti-aging benefits of Pycnogenol is commonly-cited by anti-aging supplement manufacturers. This article explains which supplements are believed to be safe during pregnancy and which ones you should avoid. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Depending on the extraction process and the source Pinus species used (P. radiata or P. pinaster), the exact composition will vary. It is found primarily in southwestern France and is used to help people with asthma, allergies, hay fever, and other health conditions.. As a skin powder, however, you can use it safely for up to six weeks. Risks. which enables users to obtain detailed information and reports based on their genome. Animal studies have found that gotu kola makes it harder . Moreover, Pycnogenol lowered the chemical, leukotrienes responsible for asthma attacks. Twenty-one patients were given Pycnogenol at 150 mg daily and 18 patients received no treatment for a period of eight weeks. No side effects were noted, unlike its synthetic counterpart. In one study, 10 patients were treated with placebo and 30 patients were treated with Pycnogenol (100 mg twice or three times daily for two months). A trial of 53 students found that pycnogenol may improve cognitive function, memory, attention, mood, and mental performance after 8 weeks [20]. (2004). In a clinical trial of 40 men with erectile dysfunction, 92.5% of the men on this combination regained normal erections after 3 months. A 2004 animal study also found that applying a gel containing pine bark extract sped up the wound-healing process. This key chemical, proanthocyanidin, is also found in high concentrations in apples, cranberries, coca, grapes, and red wine. The studies revealed that the sperm concentration greatly increased after about eight to 16 weeks of treatment, to include improved orgasmic function. A 2015 review indicates that pine bark extract can be used to treat metabolic syndrome and related disorders such as obesity, diabetes, and high blood pressure. Millions are hospitalized each year for . So it . Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. In 22 German heavy smokers, platelet aggregation was prevented by 500 mg of aspirin or 100 mg Pycnogenol. Research suggests that taking pycnogenol improves mental function and memory in both young adults and the elderly. In a study of 76 people with allergic asthma, Pycnogenol (100 mg/day) added to conventional corticosteroid inhalers for 6 months helped 55% of them reduce inhaler use frequency and dosage. In a good-quality study, 77 patients with osteoarthritis were treated with 100 mg of Pycnogenol daily and 79 patients were treated with placebo for three months. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Buy Healthy Origins Pycnogenol 100 mg (Nature's Super Antioxidant, Non-GMO, Gluten Free, Cardiovascular Support), . A total of 40 patients with retinopathy (damage to the retina part of the eye) from diabetes and other vascular causes were enrolled in one study. (10), A 15-year Dutch study was published stating that 27,939 healthy female health professionals were given aspirin or a placebo for a period of time. Pycnogenol (100 mg/day) improved menopausal symptoms and quality of life in a clinical trial of 35 women after 8 weeks [68]. (2015). This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. A study of 58 people with high blood pressure suggests that even lower doses (100 mg/day) may improve blood vessel health and reduce markers of high blood pressure (endothelin-1) after 12 weeks. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for treating conventional diabetes may be beneficial. 1 Anti-Aging Beverage, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, What Is a Marionberry? The remaining compounds are phenolic acids, which may also have antioxidant activity [1, 2]. Two doses of 100 mg of Pycnogenol were taken two to three hours before flights and two additional capsules taken six hours later then one capsule the next day. Eye health. Are there any risks to taking it? A small 2017 study examined the effects of pine bark extract in treating cardiovascular risk factors associated with menopause. In the placebo group, the retinopathy worsened; whereas, in the Pycnogenol-treated group, there was no deterioration. Pine bark extract has been studied regarding its relationship to exercise performance, oxidative stress and inflammation to body that has been imposed by exercise. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. In theory, pine bark may lower blood pressure and blood sugar level, and these effects have also been reported in some RCTs. In the study, women taking Pycnogenol were more satisfied and compliant to the regimen [24]. Some people seek to manage ADHD symptoms through an ADHD diet. DOI: Scheff SW, et al. Researchers suggest that it may have stronger benefits than elastic compression stockings. Prunes and prune juice have many health benefits. The following purported benefits of Pycnogenol are only supported by limited, low-quality clinical studies. In combination with Mirtoselect, Pycnogenol may improve blood flow to the eye and reduce eye blood pressure as shown in a trial of 38 people [81]. Various brands of pycnogenol are available. For asthma in children: 1 milligram per pound of body weight given in two divided doses. Pine bark distill has been studied regarding its relationship to exercise performance, oxidative stress and excitement to torso that has been imposed by exercise. It also may help those on blood pressure medications to reduce their dose [32]. Pine bark extract provides many benefits to the skin, including reducing the signs of aging. Our goal is to not have a single piece of inaccurate information on this website. COPD. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Masquelier was easily able to create a pine bark extract from materials that were otherwise known as waste. In oneparticular study published in Research in Pharmaceutical Sciences, researchers investigated the antibacterial activity of pine bark extract essential oil on staph infections, E. coli and pseudomonas infections. Benefits, Nutrition, Uses & How It Compares vs. Blackberries. A systematic review of 14 studies found that Pycnogenol gum or mouthwashes may reduce dental plaque, but the quality of evidence is low [58, 59]. Systolic blood pressure measures how much blood is pumping from your heart to your arteries. Pycnogenol has given indications that it might be able to benefit heart and artery health, to include reducing high blood pressure. But a month after pycnogenol was stopped, the symptoms came back, suggesting that it may need to be used regularly to achieve the benefits [41]. In one study, people with high blood pressure were examined to see how the supplement impacted their blood pressure. Diarrhea. (2017). Flavonoids and proanthocyanidins within these fruits can . This includes supporting healthy blood circulation, acting as a natural anti-inflammatory, helping to generate collagen and hyaluronic acid for improved skin health and aiding in the production of endothelial nitric oxide which helps to dilate blood . Set Ascending Direction. While OPCs found in this extract are mostly known for their antioxidant-producing benefits, these amazing compounds exude antibacterial, antiviral, anticarcinogenic, anti-aging, anti-inflammatory and anti-allergic properties. Taking pine bark extract supports healthy blood pressure. Studies were conducted in Turkey on subjects who underwent abdominal surgery to determine if the pine bark extract could help reduce the inflammation. Study participants took pine bark extract as a supplement, and it was found to be most effective in women who started out with dry skin. When pycnogenol cream was added to oral supplements in a small study of 18 people with vein ulcers, it helped ulcers heal more quickly [26]. Rating: 100%. Pycnogenol (125 mg/day) had the same effects in another study of 48 people with diabetes and high blood pressure. Pycnogenol led to a reduction of muscle cramps from 4.8 a week to 1.3 at week four. Regardless, a natural option is available and far worth the wait. Add to Cart. A 2021 review in the Arab Journal of Urology listed it first among "promising herbal remedies" for ED. Tell your doctor about any supplements you're taking, even if they're natural. The study suggests it may increase desire, arousal, lubrication, orgasm, satisfaction and reduce pain [70]. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. A 2017 review reported on the many benefits of using pine bark extract to reduce the effects of aging on skin. The combination of Panax ginseng and vitamin E also appears to have an effect. The goal of this study was to evaluate if Pycnogenol could prevent deep venous thrombosis (DVT) and superficial vein thrombosis (SVT) in eight-hour flights in 196 subjects at risk of these conditions. Taking pycnogenol daily for 2 months seems to slow or prevent further worsening of retinal disease caused by diabetes, atherosclerosis, or other diseases. In a small/preliminary study of kids with asthma, pycnogenol helped improve symptoms. The antibacterial activity was assessed indicating that the essential oil of pine bark, specifically the proanthocyanidins, were effective against P. aeruginosa, significantly inhibiting its growth. The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD) [Abstract]. Studies on human subjects have reported few side effects - even . New research has shown promising results for those dealing with erectile dysfunction (ED) and diabetes. Pycnogenol is the leading ingredient in Isotonix OPC-3, Market America's best-. According to some researchers, when you take Pycnogenol [8]: Research suggests that Pycnogenol may protect cells in the body against oxidative stress. Optimal doses of pycnogenol have not been set for any condition. Some risks associated with Pycnogenol include:, Pycnogenol and other maritime tree barks have not been studied as extensively as traditional medicine. ( 1) 2. Side effects. Potential for allergy when taken orally or used on the skin. Its been noted that taking OPCs and vitamin C supplements at the same time could increase blood pressure if you have hypertension. Pycnogenol is officially extracted from the French maritime pine (Pinus pinaster), which grows in the southwest coast of France. But what makes this miracle ingredient so amazing? Pycnogenol is a compound of natural chemicals. Pycnogenol may help reduce symptoms of melasma, a form of hyperpigmentation, possibly because it protects against UV rays. In 24 people with early eye damage from diabetes, Pycnogenol improved vision, reduced eye swelling, and improved circulation in the eye after 2 months. While the aspirin reduced the risk for cardiovascular disease and colorectal cancer, among other cancers, the risk of gastrointestinal bleeding outweighed those benefits, creating more risks to the body. Pycnogenol is the US trademarked name for an antioxidant made from Mediterranean tree bark. View as: Grid List. It also reduced LDL cholesterol at a slightly lower dose (125 mg/day) in those with type 2 diabetes in a clinical trial of 48 people after 12 weeks. The Benefits of DIM. A 2006 study found that children who took a daily pine bark extract supplement for four weeks had significantly lower levels of hyperactivity. Pycnogenol treatment reduced the need for painkillers by 58% versus one percent in the placebo-treated group. The goal of one study was to evaluate whether or not Pycnogenol could prevent edema (fluid build-up) during long-haul flights in healthy people. A good-quality study was conducted in 77 diabetic patients who received their standard antidiabetic treatment along with 100 mg Pycnogenol a day or placebo for 12 weeks. (13). Note that each number in parentheses [1, 2, 3, etc.] New research shows . One study found that Pycnogenol may reduce the activity of the inflammatory enzymes COX1 and COX2, similar to how NSAID drugs work. However, healthy people are not immune and can also develop mild infections, in particular after being in improperly chlorinated hot tubs or swimming pools. Enzogenol, a slightly different pine bark extract, may help improve brain function after mild concussions. Here are 12 benefits of ginkgo biloba. You can find out your systolic blood pressure by looking at the top number of a blood pressure test. Video: Why You Need Zinc and Where to Find It. Disease of the retina in the eye. Although these may still be high quality, the active compounds are more likely to vary. $47.99. Proper nutrition is essential for ADHD treatment. Pycnogenol has been shown to help relieve the pain associated with osteoarthritis by keeping blood chemicals from attacking the cartilage. editor, The Gale Encyclopedia of Alternative Medicine, third edition, 2009. You can learn more about how we ensure our content is accurate and current by reading our. (5). Sort By. Trees of this pine have been naturalized in Australia and New Zealand, where most Enzogenol is now made [7]. There were 88 in the control group and 81 in the Pycnogenol group. Enzogenol, a slightly different pine bark extract, improved cognitive function in a clinical trial of 42 older men after 5 weeks of supplementation [23]. after four weeks of treatment, Pycnogenol-treated patients showed definite evidence of improved in small blood vessel functions and circulation as compared to those not treated. Learn more about how to get even skin tone. A clinical trial of 60 health professionals found that Pycnogenol (150 mg/day) may improve cognitive function, attention, mental performance and specific professional skills after 12 weeks. 10 Day Erection Delay Sex Pills. It also may enhance swimming, biking, and running scores in professional athletes preparing for a triathlon (at 150 mg/day). From diabetes and sexual function to sports performance and beautiful skin, pine bark extract may be worth exploring to provide results youre looking to achieve. The positive improvements in symptoms were greater among those taking Pycnogenol. Clearer skin, healthier hair there are a lot of claims about the health benefits of biotin. Researchers suggest that it may have stronger benefits than elastic compression stockings. A study was conducted by the Guang An Men Hospital of Chinese Medical Science Research Institutewith 77 diabetes type II patients to determine if theextract of the French Maritime pine bark provided anti-diabetic effects. Researchers suggest this benefit may be due to an increase in glutathione and SOD, two antioxidants that may reduce inflammation and oxidative stress in Crohns [76]. is a clickable link to peer-reviewed scientific studies. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. A trial of children with ADHD found that Pycnogenol may improve attention, possibly by increasing the total antioxidant status and reducing DNA damage. Make sure to seek out the advice of your physician prior to using pine bark extract or the branded name, Pycnogenol. Circulation and Jet Lag on Long Flights. In contrast, almost 20% of the participants on inhalers alone had to increase their dosage. Berberine is a compound extracted from several plants. All Pycnogenol-treated patients responded favorably in contrast to placebo treatment. However, these studies appear to be methodologically sound and reliable, with no blatant errors in the study design and data collection. Boost gastrointestinal health. Some small studies suggest it may also protect against coronary artery disease and blood clots. Seems like it must be pretty amazing, but lets look closer. The combination of L-arginine and Pycnogenol may help in erectile dysfunction by boosting nitric oxide, which potentially could improve blood flow in men [66]. DOI: Dvorkov M, et al. This review noted that pine bark extract may also help with: In addition to its skin-healing properties, pine bark extract also shows promise for helping children manage ADHD symptoms. Pycnogenol seems well-tolerated for use in adults for up to 6 months. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. In a clinical trial of 116 women, Pycnogenol (60 mg/day) reduced menstrual pain and the need for additional painkillers, taken over 2 cycles. Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. In one study, 200 mg a day of Pycnogenol taken three hours prior to the first cigarette for the day for two months significantly reduced cigarette-induced platelet aggregation. DOI: Trebatick J, et al. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. He later extracted proanthocyanidins from the European coastal pine tree, which he named Pycnogenol.. Consider pine bark extract through a conversation with your physician or a functional medicine doctor. While these results are promising, there isnt enough research to fully understand the effect of antioxidant levels on ADHD symptoms. That said, there are some instances where this extract may possibly be effective. Pine bark extract can make a great addition to your nutritional arsenal for its potent antioxidant support, as well as its added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support.